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EC number: 271-080-4
CAS number: 68515-39-9
A complex combination of hydrocarbons produced by the esterification of phthalic anhydride with tridecyl alcohol. It consists predominantly of C13 primary aliphatic alcohols, C11-13 paraffins and saturated and unsaturated C26 ethers and boiling in the range of approximately 120°C to 280°C (248°F to 536°F).
This in vitro study was performed to assess the eye irritation potential of the study substance by means of the Human Cornea Model Test.
The study substance proved to be an MTT reducer in the MTT pre-test. Therefore, additional tests with freeze-killed tissues had to be performed. The viability values resulted in these additional tests were used to correct the values gained in the normal tests.
Each 50 μL of the study substance, the negative control (deionised water) or the positive control (methyl acetate) were applied to each of duplicate tissues for 30 minutes.
The mean OD of the tissue replicates treated with the negative control was > 0.8 and < 2.5, thus showing the quality of the tissues.
Treatment with the positive control induced a decrease below 50% viability compared with the negative control value in the relative absorbance, thus ensuring the validity of the test system.
The difference of relative viability between the two relating tissues was < 20% in the same run (for study substance tissues, positive and negative control tissues).
Irritating effects were not observed following incubation with the study substance. Compared with the value of the negative control, the mean absorption value corresponding to the tissue viability did not decrease below 60% (determined value for the study substance: 100.45%).
In conclusion, it can be stated that in this study and under the experimental conditions reported, the study substance does not need to be classified according UN GHS.
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