Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-160-5
CAS number: 130786-09-3
The study was performed according to OECD TG 420
and EU Method B.1 bis Acute Toxicity (Oral) and in accordance with GLP
to assess the acute oral toxicity of the test material following a
single oral administration in the female Sprague-Dawley Crl : CD (SD)
IGS BR strain rat by the fixed dose method. The test item was
administered by oral gavage in a solution in arachis oil BP in an
initial sighting study at 300 mg/kg bw and following an absence of
toxicity then at 2000 mg/kg bw. Subsequently, a further group of four
fasted females was given a single oral dose of test item, at a dose
level of 300 mg/kg body weight. The animal treated at a dose level of
2000 mg/kg was humanely terminated on 1 day after dosing. Clinical signs
were noted during the day of dosing in the animal treated at a dose
level of 2000 mg/kg. There was no mortality at a dose level of 300
mg/kg. There were no clinical signs of systemic toxicity and all animals
showed expected gains in bodyweight over the study period at a dose
level of 300 mg/kg. Abnormalities noted at necropsy of the animal
treated at a dose level of 2000 mg/kg, that was humanely terminated,
were abnormally red lungs and haemorrhage of the gastric mucosa,
non-glandular region of the stomach and small and large intestines. No
abnormalities were noted at a dose level of 300 mg/kg. Under the
conditions of this study, the oral LD50 was estimated to be in the range
of 300 - 2000 mg/kg bw in the female Sprague-Dawley CD strain rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again