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EC number: 485-430-0
CAS number: 923954-49-8
Repeated dose toxicity:
- oral: NOAEL = 1000 mg/kg bw/d (OECD 407)
In accordance with Annex IX, section 8.6.2,
column 2, a subchronic toxicity study has been waived. For further
information please refer to the respective study record.
Repeated dose toxicity was evaluated in a study performed under GLP
according to OECD guideline 407, where groups of five male and five
female Wistar were dosed by gavage with concentrations of 100, 300 1000
mg/kg bw/d for 28 days (BASF, 2008). Beside observations for clinical
sings and mortality, hematology, clinical chemistry, urinalysis were
performed and behavioral parameters were recorded. At the end of the
study, serum metabolites were analyzed and compared to the profiles
known toxic substances of the MetaMap Tox-database. As result, no
substance-related adverse effects were noted in both males and females
at all dose level and the test substance did not match established
metabolite profiles for specific toxicity. Thus, the NOAEL was found to
be 1000 mg/kg bw/d.
Based on the found effect level obtained in an OECD guideline study, no
classification according to EU and GHS criteria is necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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