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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

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Endpoint:
activated sludge respiration inhibition testing
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
pentane-2,4-dione is the hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
Qualifier:
equivalent or similar to guideline
Guideline:
DIN 38412-27 (Pseudomonas putida Zellvermehrungshemmtest)
GLP compliance:
not specified
Test organisms (species):
Pseudomonas putida
Test type:
static
Water media type:
freshwater
Total exposure duration:
16 h
Key result
Duration:
16 h
Dose descriptor:
other: Toxicity threshold
Effect conc.:
>= 67 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
yes
Conclusions:
16h Toxicity threshold (= EC3) tested on Pseudomonas putida was 67 mg/l for pentane-2,4-dione
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
other: DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
Principles of method if other than guideline:
DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Pseudomonas putida
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
16 h
Key result
Duration:
16 h
Dose descriptor:
other: toxicity threshold
Effect conc.:
ca. 1 050 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: mean extinction value
Validity criteria fulfilled:
not applicable
Conclusions:
The toxicity threshold (TT) of 2-propanol to Pseudomonas putida (cell multiplication) is 1050 mg/l based on a 16 h test.

Description of key information

Key value for chemical safety assessment

EC50 for microorganisms:
67 mg/L

Additional information

No studies were conducted on the target substance. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic ethanol, 2-propanol and acetylacetone. The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of acetylacetone and 2-propanol are well-investigated are used for CSA.