Ethoxybis(pentane-2,4-dionato-O,O')(propan-2-olato)titanium

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to aquatic algae and cyanobacteria

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 2

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

pentane-2,4-dione is the hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

GLP compliance:

not specified

Test organisms (species):

other: Algae: green algae, mainly Scenedesmus sp

Duration:

24 h

Dose descriptor:

EC10

Effect conc.:

ca. 100 mg/L

Nominal / measured:

nominal

Basis for effect:

other: inhibition of assimilation

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 300 mg/L

Nominal / measured:

nominal

Basis for effect:

other: inhibition of assimilation

Validity criteria fulfilled:

yes

Conclusions:

After an exposure time of 24 hours the EC10 and EC50 values were determined to be 100 mg/l and > 300 mg/l, respectively. The EC10 value from this test can be regarded as long-term effect value for algae.

Reference 3

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

no guideline available

Principles of method if other than guideline:

The concentration of the algal suspension is measured turbidimetrically and expressed by the extinction of the primary light of the monochromatic radiation at 578 nm for a layer of 10 mm thickness.

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Scenedesmus quadricauda

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

7 d

Key result

Duration:

7 d

Dose descriptor:

other: toxicity threshold

Effect conc.:

ca. 1 800 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: mean extinction value

Validity criteria fulfilled:

not applicable

Conclusions:

The toxicity threshold (TT) of 2-propanol to Secenedesmus quadricauda is 1800 mg/l based on a 7 d test.

Key value for chemical safety assessment

EC50 for freshwater algae:

300 mg/L

EC10 or NOEC for freshwater algae:

100 mg/L

Additional information

No studies were conducted on the target substance. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic ethanol, 2-propanol and acetylacetone. The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of acetylacetone and 2-propanol are well-investigated are used for CSA.