Ethoxybis(pentane-2,4-dionato-O,O')(propan-2-olato)titanium

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

pentane-2,4-dione is the hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

no

Test organisms (species):

Pimephales promelas

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 104 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow though method, tesed on Pimephales promelas was 104 mg/l for pentane-2,4-dione.

Reference 3

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data obtained from peer-reviewed secondary source.

Justification for type of information:

Data obtained from peer-reviewed secondary source.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Constant-flow procedure first cited at Alabaster and Abram (1965).

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Rasbora heteromorpha

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Key result

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

ca. 7 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 900 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 200 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

96-h LC50 (Rasbora heteromorpha) toxicity of 2-propanol is 4200 mg/L based on the nominal concentrations.

Reference 4

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

pentane-2,4-dione is the hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

not specified

Test organisms (species):

Lepomis macrochirus

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 60.1 mg/L

Basis for effect:

mortality (fish)

Details on results:

Confidence interval: 50.3 - 71.8 mg/l

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow though type stuyd, tested on bluegill fish was 60.1 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

60.1 mg/L

Additional information

No studies were conducted on the target substance. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic ethanol, 2-propanol and acetylacetone. The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of acetylacetone and 2-propanol are well-investigated are used for CSA.