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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Principles of method if other than guideline:
An excess of product is shaked with solvent during 24 hours at 20 deg C. After filtration the concentration in solution is determined with spectrometry.
GLP compliance:
not specified
Medium:
methanol
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
ethanol
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 2-propanol
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: dichloromethane
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 2-propanone
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: ethyl acetate
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: methyl benzene
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 4-methyl-2-pentanone
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 2-butanon
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: 1-methoxy-2-propanol
Solubility:
> 200 g/L
Temp.:
20 °C

Results solubility in organic solvents:

 Solvent Solubility in g/L solution 
 N,N-dimethylacetamide > 200
 N,N-dimethylformamide > 200 
acetonitrile  > 200 
tetrahydrofurane  > 200 
acetic acid  > 200
acetic acid/water (10/90, v/v) (pH = 2.3)  > 200
Conclusions:
The solubility of T002675 was determined in different organic solvents to be > 200 g/L.

Description of key information

A K4 study reports various solubilities of test substance in different organic solvents (J&J PRD).

Key value for chemical safety assessment

Additional information

solvent  solubility g/L (20°C)
   
methanol  >200
   
ethanol >200
   
2-propanol  >200
   
dichloromethane  >200
   
2-propanone  >200
   
ethyl acetate  >200 
   
methylbenzene  >200
   
4-methyl-2-pentanone  >200
   
2-butanone  >200
   
1-methoxy-2-propanol  >200
   
N,N-dimethylacetamide >200
   
acetic acid  >200
   
THF  >200
   
 N,N-dimethylformamide  >200
   
 acetonitrile >200 
   
 acetic acid/water (10/90, v/v) (pH=2.3)  >200