Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-851-9 | CAS number: 72797-41-2
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August to november 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The determination was carried out by a gas comparison pycnometer method, using a procedure designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
Test material
- Reference substance name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- EC Number:
- 276-851-9
- EC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Cas Number:
- 72797-41-2
- Molecular formula:
- C21H25ClN2O4S
- IUPAC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Test material form:
- solid: crystalline
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch 18114773 - Purity > 99.5%
Instrument: Multi-Pycnometer, Quantachrome, Syosset, N.Y., USA
Calibration sphere: A stainless steel sphere with a known volume (Vcal = 56.559 cm3)
Gas: Helium
Results and discussion
Densityopen allclose all
- Key result
- Type:
- relative density
- Density:
- ca. 1.33
- Temp.:
- 20 °C
- Type:
- density
- Density:
- ca. 1 330 kg/m³
- Temp.:
- 20 °C
Applicant's summary and conclusion
- Conclusions:
- Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.
The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing thevolume of that substance. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1,and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance.
Therefore, it was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant
The density of the test item has been determined to be 1.23 x 10E3 kg/m3 at 19.0 ± 1.0 °C; relative density: 1.23. - Executive summary:
The density of the test item has been determined to be 1.23 x 10E3 kg/m3 at 19.0 ± 1.0 °C; relative density: 1.23.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
