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EC number: 276-851-9
CAS number: 72797-41-2
This study was performed to investigate the potential of 1574 ACIDE
CRIST to induce gene mutations according to the plate incorporation test
(experiment I) and the pre-incubation test (experiment II) using the
Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100, and the
Escherichia coli strain WP2 uvrA.
The assay was performed in two independent experiments both with and
without liver microsomal activation (S9 mix). Each concentration,
including the controls, was tested in triplicate. The test item was
tested at the following concentrations:
Pre-Experiment/Experiment I: 3; 10; 33; 100; 333; 1000; 2500; and 5000
Strain TA 100: 10; 33; 100; 333; 1000; 2500; and 5000 μg/plate
The remaining strains: 33; 100; 333; 1000; 2500; and 5000 μg/plate
The test item precipitated in the overlay agar in the test tubes at 5000
μg/plate with and without S9m in both experiments. Precipitation of the
test item in the overlay agar on the incubated agar plates was observed
at 5000 μg/plate with S9 mix. No precipitation of the test item was
observed on the incubated agar plates without S9 mix.
The plates incubated with the test item showed normal background growth
up to 5000 μg/plate with and without S9 mix in all strains used.
No toxic effects, evident as a reduction in the number of revertants
(below the indication factor of 0.5), occurred in all strains with and
without metabolic activation, except of strain TA 100.
No substantial increase in revertant colony numbers of any of the five
tester strains was observed following treatment with 1574 ACIDE CRIST at
any dose level, neither in the presence nor absence of metabolic
activation (S9 mix). There was also no tendency of higher mutation rates
with increasing concentrations in the range below the generally
acknowledged border of biological relevance.
Appropriate reference mutagens were used as positive controls and showed
a distinct increase of induced revertant colonies.
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