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EC number: 908-205-5
CAS number: -
Acute inhalation toxicity studies were performed on category members.
Rats, guinea pigs, and mice were exposed to the category members in
exposure chambers for a set period of time. Upon removal from the
chamber several animals were sacrificed to observe sections of their
lungs, spleen, liver and kidneys. The remaining animals were observed
for 2 weeks, weighed, sacrificed and grossly examined. There were no
deaths in the studies. Weight gains were normal and at necropsy no
grossly observable lesions were noted. Inhalation LC50 values of
category members range from > 20 mg/L to > 41 mg/L. Based on these
results, the category members are not classified for acute inhalation
toxicity according to GHS.
MTDID 22327 is a member of the Perfluorinated Organic Chemicals, C5-C18,
category. Unlike most members of the category, MTDID 22327 is a UVCB
consisting mostly of perfluoro-N-methylmorpholine, a mixture of C5-C7
perfluoroamines, and perfluorohexane isomers. However, all of these
chemicals stem from the same manufacturing process, have similar
physicochemical properties including high vapor pressure and low water
solubility relative to the hydrocarbon analogs (e.g., hexanes v.
perfluorohexanes), and also lack any chemically reactive groups, which
forms the technical basis for the category. Members of this category
are fully fluorinated, meaning that fluorine, rather than hydrogen, is
bonded to all carbon atoms in the molecule. Fluorine is the most
electronegative of the elements (fluorine has an electronegativity of
3.98 on the Pauling scale, as compared to 2.55 for carbon, 3.04 for
nitrogen or 2.20 for hydrogen). This electronegativity is expected to
dominate over all other aspects of substance chemistry and is the
underlying basis for similarity of substances in this category. For
example, strong electron withdrawing in perfluorinated tertiary amines
results in a molecule with essentially no lone pair influence, and which
has chemistry more similar to a branched, perfluorinated alkane than any
other structure. Because these substances exhibit similar
physicochemical properties they can be considered to constitute a
chemical category. The data gap for acute inhalation lethality can
therefore be addressed by many-to-one read-across between category
Because these substances exhibit similarity in their physicochemical
properties and toxicological properties in mammals, and because
available data indicates that parent molecules are not reactive toward
biological molecules and cannot undergo bioactivation by normal
enzymatic processes, they can be considered to constitute a chemical
category. Data gaps for partitioning properties, mammalian and
ecological toxicity can therefore be addressed by read-across and/or
trend analysis between category members. The readacross is considered
reliable with restrictions and the result is suitable for use in Risk
Assessment, Classification & Labelling, and PBT Analysis. See section 13
for a fuller discussion of the category approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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