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EC number: 908-205-5
CAS number: -
MTDID 22327 is volatile (vapor pressure, 213 mm Hg at 20 °C) and of low
water solubility (range for predominant constituents, 0.679 μg/L to 758
µg/L at ca. 23 - 24 °C). A range of Henry's Law constants (expressed as
the ratio of vapor phase partial pressure of constituent over aqueous
phase concentration) of 171 - 4020 atm∙m³/mol, at 22 °C was established
by read-across from category members. A range of log Kow values of 4.3
- 6.14 at 23 °C was similarly established by read-across from
predominant constituents. However, it is not expected that MTDID 22327
will have a significant presence in the aquatic compartment, and
bioaccumulation in aquatic organisms is not expected.
MTDID 22327 is not expected to partition from the atmosphere to moist
soils or surface waters. MTDID 22327 is manufactured for export; it is
not expected to be released to aquatic systems or soils. Upon direct
release of MTDID 22327 to the aquatic compartment, the chemical would be
expected to volatilize rapidly. However, as noted MTDID 22327 release
is entirely to the atmosphere. MTDID 22327 is not expected to partition
to aquatic compartments from the atmosphere, therefore no exposure to
aquatic organisms is expected.
Bioaccumulation studies are not required at this annual volume, and no
studies were done on bioaccumulation of MTDID 22327. Based on the log
Kow range of 4.3 – 6.14, some constituents of this substance would be
considered bioaccumulative in aquatic organisms; the predominant
constituent with its log Kow of 4.3 would not. However, substantial
bioaccumulation of MTDID 22327 in aquatic organisms is not expected due
to lack of exposure in aquatic systems. MTDID 22327 is expected to
reside entirely in the atmospheric compartment, so air breathing
organisms were evaluated for bioaccumulation potential. According to
Chapter R.188.8.131.52 of the Technical Guidance (Other indication of
"For air-breathing organisms, respiratory elimination occurs via
lipid-air exchange, and such exchange declines as the octanol-air
partition coefficient (Koa) increases, with biomagnification predicted
to occur in many mammals at a log Koa above 5. Such biomagnification
does not occur if the substance and its metabolites are rapidly
eliminated in urine (i.e. have a log Kow of around 2 or less). Thus the
bioaccumulation potential in air-breathing organisms is a function of
both log Kow and log Koa. In contrast, respiratory elimination in
non-mammalian aquatic organisms occurs via gill ventilation to water,
and this process is known to be inversely related to the log Kow (hence
an increase in log Kow results in a decrease in the rate of elimination
and hence increase in the accumulation potential)."
Log octanol-air partition coefficient (log Koa) values ranging from 0.39
to 1.52 were calculated for MTDID 22327 using the relationship:
Koa (unitless) = Kow / Kaw
Where Kow is octanol:water partition coefficient and Kaw is the
dimensionless Henry’s Law constant. Input data were derived from
category members. As per Kelly and Gobas (1), chemicals with log Koa < 4
do not biomagnify regardless of the Kow because of efficient
elimination via air exhalation (or, in this case, extremely inefficient
absorption via air inhalation). According to the classification scheme
proposed in Chapter R184.108.40.206, MTDID 22327 is a non-polar volatile (high
log Kow and low log Koa), and is not expected to bioaccumulate in
air-breathing organisms. As stated, the potential to accumulate in
aquatic organisms is mitigated by the lack of relevance of the aquatic
exposure pathway. Therefore, bioaccumulation of MTDID 22327 in
terrestrial or aquatic organisms is not expected.
1) Kelly, B.C. and F.A.P.C. Gobas. 2003. An Arctic Terrestrial
Food-Chain Bioaccumulation Model for Persistent Organic Pollutants.
Environ. Sci. Technol Vol. 37, No. 13, pp 2966–2974.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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