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EC number: 908-205-5
CAS number: -
Experimental partition coefficient data are available for two
constituents of MTDID 22327 (perfluoromethylmorpholine, PMM) and
(perfluorohexanes; PFHx). In addition, two constituents are common to
MTDID 22327 and MTDID 50908. The four constituents described have the
highest typical concentrations (>1%) in MTDID 22327. Average Kow values
are not reported in all of the source studies. Individual Kow ratios are
reported below, with average Kow calculated where necessary
Table, Kow values from source studies
n-octanol: water volume ratio
MTDID 50908 Components A and H¹
MTDID 50908 Component D²
1, data for unresolved isomeric mixture of constituent
2, constituent is
3, Only two replicatate were done for PMM and PFHx
The Log n-octanol:water coefficient of MTDID 22327 was determined using
a category approach wherein the coefficients of known constitituents are
used to define the range. The resulting range was 4.3 to 6.14 at ca. 23
- 25 °C. The predominant constituent had the lowest measured log Kow.
The validity of this approach to categorically group these types of
substances was determined to be reliable with restrictions based on the
similarity of chemical functional groups, molecular weights, water
solubilities, and vapor pressures. Since the source data are for
constituents of MTDID 22327, they provide the best estimate of the range
of partition coefficient for MTDID 22327. The source data are from
GLP-compliant or ISO 17025-compliant studies which used national
standard test guidelines, and they are considered reliable or reliable
with restriction. This study is pertinent to the fate of MTDID 22327 and
may be used for Risk Assessment, Classification & Labelling, and PBT
Perfluoro-N-methylmorpholine, PMM, CAS# 382-28-5
Perfluorohexanes, PFHx, CAS# 1064697-81-9
The organic carbon adjusted adsorption coefficient (log Koc) MTDID 22327
was calculated from the read across values for log Kow values of the
predominant constituents. The range was 3.6 - 5.1 using the equation
provided for predominantly hydrophobic chemicals in the European
Chemicals Bureau: Technical Guidance Document on Risk Assessment,
Chapter 4. Since the source data are for constituents of MTDID 22327,
they provide the best estimate of the range of log Koc for MTDID 22327.
The source data for the calculation were obtained using national
standard test guidelines and were GLP- or ISO 17025-compliant. The
calculation is considered reliable with restrictions and is suitable for
Risk Assessment, Classification & Labelling, and PBT Analysis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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