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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose for cross-reference:
read-across: supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1999

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Tests in inhalation chambers
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N-hexane
EC Number:
203-777-6
EC Name:
N-hexane
Cas Number:
110-54-3
Molecular formula:
C6H14
IUPAC Name:
hexane
Test material form:
liquid
Specific details on test material used for the study:
hexane (isomer composition and purity were not specified)

Test animals / tissue source

Species:
human

Test system

Vehicle:
other: air (tested in inhalation chambers)
Duration of treatment / exposure:
3-5 min
Number of animals or in vitro replicates:
10 volunteers

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
mean
Time point:
other: after 3-5 min. in inhalation chamber
Score:
ca. 0
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Hexane is not irritant to the eye, when humans are exposed up to 500ppm in the air for a few minutes.
Direct contact with n-hexane vapor (3000 ppm for 24 wk with 5 d/wk for 8 hr/d) with the eyes of rabbits resulted in lacrimation and hyperemia of the conjunctivae.