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EC number: 203-523-4
CAS number: 107-83-5
The changes in MNCV (distal) are shown in Fig. 4. MNCV (distal) in
n-hexane group was significantly less than the control after four weeks'
administration. But there was no significant difference between MNCVs
(distal) in 2-methylpentane, 3-methylpentane or methylcyclopentane group
and the control.
The changes in MNCV (proximal) are shown in Fig. 5. MNCV (proximal) in
n-hexane group was significantly less than the control after six weeks'
administration. MNCVs (proximal) in the 2-methylpentane and
were significantly less than the control after eight weeks'
The summary of the results is shown in Fig. 6. The results demonstrated
that the n-hexane group showed a distinct impairment of the functional
states of the peripheral nerve, the methylcyclopentane and
2-methylpentane groups showed
only slight impairment of them, and 3-methylpentane group barely showed
The ratios of the conduction velocities and distal latencies to the
predosing ones were calculated and compared between each
solvent-administered group and the control group (Fig. 7). MNCV (distal)
significantly differed from that of the
control even in 3-methylpentane group after eight weeks' administration.
There were no significant differences in distal latency.
Commercial hexane which caused polyneuropathy in many workers contained
10-40 % of 2-methylpentane, 3-methylpentane and methylcyclopentane in
addition to n-hexane. The hexacarbon compounds methyl n-butyl ketone,
2,5-hexanedione and etc were shown to be neurotoxic like n-hexane.
Therefore, 2-methylpentane, 3-methylpentane and methylcyclopentane which
are also hexacarbon compounds were suspected to be neurotoxic, but their
neurotoxicity had not been sufficiently investigated.
The present experiment was performed to clarify their neurotoxicity by
measuring the nerve conduction velocity in the rat's tail Thirty rats
were divided into five groups of 5-7 rats. n-Hexane, 2 -methylpentane,
3-methylpentane and methylcyclopentane were diluted with olive oil and
orally administered daily for eight weeks. The body weight, motor nerve
conduction velocity, motor distal latency and mixed nerve conduction
velocity were measured before administration, after two, four, six and
eight weeks' administration.
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