Registration Dossier
Registration Dossier
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EC number: 203-523-4 | CAS number: 107-83-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test substance was applied within a glass ring to the volar forearm of a volunteer and left on the skin for 5 min.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-hexane
- EC Number:
- 203-777-6
- EC Name:
- N-hexane
- Cas Number:
- 110-54-3
- Molecular formula:
- C6H14
- IUPAC Name:
- hexane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- n-hexane, analytical grade
Test animals
- Species:
- other: human
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- single dose, 1.5 ml on an area of 3.1 cm²
- Duration of treatment / exposure:
- 5 min.
- Observation period:
- 60 min.
- Number of animals:
- 1 human volunteer
Results and discussion
In vivo
Results
- Irritation parameter:
- other: visual inspection
- Time point:
- other: 10-20 minutes
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Remarks:
- A slight transient erythema was observed after 10-20 minutes exposure to 1.5 mL n-hexane. Stinging and/or burning sensation reported by the volunteer. Application of 0.1 mL neat n-hexane did not cause clinical signs or affect blood flow.
- Irritant / corrosive response data:
- increased blood flow, slight erythema, stinging and/or burning sensation
fully reversible within 60 min.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Analogue substance n-hexane caused fully reversible skin irritation at a human volunteer.
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