Registration Dossier
Registration Dossier
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EC number: 212-464-3 | CAS number: 819-83-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- route not specified, presumed intravenous
- Type of information:
- other: information reported on a patent record
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other: Patent record
- Title:
- Offenlegunsschrift 25 02 735 Infusionslösungen mit Salzen des Glycerophosphats
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium β-glycerophosphate
- EC Number:
- 212-464-3
- EC Name:
- Disodium β-glycerophosphate
- Cas Number:
- 819-83-0
- Molecular formula:
- C3H7O6P.2Na
- IUPAC Name:
- disodium β-glycerophosphate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 400 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- An acute toxicity test on rats was performed to determine the safety of using glycerophosphate salt for IV solutions (administration type not specified, but it could be presumed it was IV).
Beta-Glycerophosphate (CAS 819-83-0) is not toxic to rats. The LD50 was determined to be 3400 mg/kg bw for rats.
- Executive summary:
An acute toxicity test on rats was performed to determine the safety of using glycerophosphate salt for IV solutions (administration type not specified, but it could be presumed it was IV)
Beta-Glycerophosphate (CAS 819-83-0) is not toxic to rats. The LD50 was determined to be 3400 mg/kg bw for rats.
Alpha-Glycerophosphate was also tested. The LD50 was determined to be 3800 mg/kg bw in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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