Disodium β-glycerophosphate

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 July 2017 - 13 November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

from 27 July 1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Disodium β-glycerophosphate

EC Number:

212-464-3

EC Name:

Disodium β-glycerophosphate

Cas Number:

819-83-0

Molecular formula:

C3H7O6P.2Na

IUPAC Name:

disodium β-glycerophosphate

impurity 1

Reference substance name:

Disodium α-glycerophosphate

EC Number:

216-304-3

EC Name:

Disodium α-glycerophosphate

Cas Number:

1555-56-2

Molecular formula:

C3H9O6P.2Na

IUPAC Name:

disodium 2,3-dihydroxypropyl phosphate

impurity 2

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

Test material form:

solid: particulate/powder

Details on test material:

Batch No.: 11769400
Storage: 15-25°C

Results and discussion

Melting / freezing point

Key result

Atm. press.:

1 009.1 hPa

Decomposition:

yes

Decomp. temp.:

ca. 50 °C

Remarks on result:

other: Melting of the test item was not observed below the temperature of decomposition, therefore the test item has no melting temperature.

Any other information on results incl. tables

Starting at a temperature of 50 °C a first exothermic effect with an energy release of -30 J/g can be observed. This effect is directly followed by an endothermic effect, starting at 70 °C. A second endothermic effect is detected starting at a temperature of 250 °C. Subsequently a second exothermic effect starting at 340 °C with an energy release of -50 J/g is observed.

No.	Sample weight (mg)	Onset of effect (°C)	Range of effect (°C)	Weight loss (mg)	Atmospheric pressure (hPa)
1	10.73	50 70 250 340	50 - 70 (exo) 70 -130 (endo) 250 -330 (endo) 340 -410 (exo)	3.70	1009.1
2	6.67	50 70 250 340	50 - 70 (exo) 70 -120 (endo) 250 -330 (endo) 340 -410 (exo)	2.43	1009.1

During the heating phase two endothermic effects were observed in the temperature range of 70 – 130 °C and 250 – 330 °C, which cannot be assigned to the melting of the test item, because an exothermic effect is observed previously at 50 °C. In correlation to the determination of the thermal stability (see 4.19), the test item showed a decomposition starting at approx. 50 °C. Thus, no melting of the test item could be detected up to its decomposition starting at 50 °C under atmospheric pressure.

Applicant's summary and conclusion

Conclusions:

The test item Disodium beta-glycerophosphat (CAS no. 819-83-0) has no melting point at atmospheric pressure (1009 hPa) up to the decomposition temperature of approx. 50 °C, as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Executive summary:

The test item Disodium beta-glycerophosphat (CAS no. 819 -83 -0) has no melting point at atmospheric pressure (1009 hPa) up to the decomposition temperature of approx. 50 °C, as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).