Registration Dossier
Registration Dossier
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EC number: 944-188-0 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The composition of the test substance (iron ore) is unknown
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Triiron tetraoxide
- Details on test material:
- Iron ore dust (not further specified)
Constituent 1
Results and discussion
- Details on results:
- Cytotoxicity of iron ore dust was related to the lipid peroxidation
Any other information on results incl. tables
Phagocytic activity of alveolar macrophages on S. cerevisiae was depressed, LDH activity was increased, and potassium concentration in the cells was reduced. Cells were morphologically not damaged, but lipid peroxidation was increased.
Applicant's summary and conclusion
- Executive summary:
Cytotoxicity of iron ore dust was related to the lipid peroxidation
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