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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other above-ground organisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to other above-ground organisms
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is not based on international accepted testing guidelines, but according to accepted scientific standards.
Qualifier:
no guideline followed
Principles of method if other than guideline:
23 days dietary toxicity study with rats
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
rat
Details on test organisms:
Sprague-Dawley rats
Study type:
laboratory study
Limit test:
no
Total exposure duration:
23 d
Details on test conditions:
- Test conditions: rats, 45-50 g at the start of the experiment, were individually housed in stainless steel suspended cages with deionised water and food available all the time in a temperature controlled room. After being habituated to the basal diet for 3 days, rats were given diets containing normal or ten times normal amounts of niacin together with the Pb doses
- Diet: semi-purified diet: casein, corn oil, cellulose, vitamins, minerals, glucose. Pb concentration in basal diet: not indicated
Nominal and measured concentrations:
nominal added Pb concentrations: 0 (control)-50-150-300 mg Pb/kgww
Reference substance (positive control):
no
Duration:
23 d
Dose descriptor:
NOEC
Effect conc.:
150 mg/kg diet
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Pb
Basis for effect:
other: heme content
Duration:
23 d
Dose descriptor:
other: NOEL
Effect conc.:
25.5 other: mg/kg bw/day
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Pb
Basis for effect:
other: heme content
Duration:
23 d
Dose descriptor:
other: LOEL
Effect conc.:
51 other: mg/kg bw/day
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Pb
Basis for effect:
other: heme content
Details on results:
- Ratio daily food intake / body weight = 0.17 kgww / day / kg body weight
- The NOEL value is 25.5 mg/kgbw/day.
- LOEC value is 300 mg/kgbw
Reported statistics and error estimates:
no further information on statistics are reported
Validity criteria fulfilled:
yes
Conclusions:
This study is not based on international accepted testing guidelines, but considered reliable. A 23 days NOEC of 150 mg Pb/kg diet for heme content was obtained.

Description of key information

The chosen value is based on data for lead. The data were from a 23 day study on Sprague-Dawley rats (male).

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for mammals:
150 mg/kg food

Additional information

wet weight