Registration Dossier
Registration Dossier
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EC number: 279-935-3 | CAS number: 82338-76-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of Terphenyl, hydrogenated (CAS no: 61788-32-7) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of Terphenyl, hydrogenated (CAS no: 61788-32-7) in Rat.
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- IFA GESTIS, GESTIS SUBSTANCE Database, 2017
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset of Terphenyl, hydrogenated (CAS no: 61788-32-7).
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 18 – FEB - 2000.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute Oral Toxicity Study of Terphenyl, hydrogenated (CAS no: 61788-32-7) in Rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Terphenyl, hydrogenated
- EC Number:
- 262-967-7
- EC Name:
- Terphenyl, hydrogenated
- Cas Number:
- 61788-32-7
- IUPAC Name:
- Terphenyl, hydrogenated
- Details on test material:
- Name - Terphenyl, hydrogenated
InChI - 1S/C18H22/c1-3-7-15(8-4-1)17-11-13-18(14-12-17)16-9-5-2-6-10-16/h1,3,5,9,11-16H,2,4,6-8,10H2
Smiles - C1CC=CC(C1)c2ccc(cc2)C3CCC=CC3
- Molecular weight (if other than submission substance):238.3718 g/mole
- Substance type:Organic
- Physical state:Yellowish liquid
Constituent 1
- Specific details on test material used for the study:
- Name - Terphenyl, hydrogenated
InChI - 1S/C18H22/c1-3-7-15(8-4-1)17-11-13-18(14-12-17)16-9-5-2-6-10-16/h1,3,5,9,11-16H,2,4,6-8,10H2
Smiles - C1CC=CC(C1)c2ccc(cc2)C3CCC=CC3
- Molecular weight (if other than submission substance):238.3718 g/mole
- Substance type:Organic
- Physical state:Yellowish liquid
Test animals
- Species:
- rat
- Strain:
- other: hooded rat
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 17500 mg/kg bw
- No. of animals per sex per dose:
- 6 Male/dose
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 17 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed at 17500 mg/kg bw
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 17500 mg/kg bw, when hooded rats was treated with Terphenyl, hydrogenated (CAS no: 61788-32-7) via oral route.
- Executive summary:
Acute oral toxicity study was conducted in 6 Hooded Malerats by using Terphenyl, hydrogenated (CAS no: 61788-32-7) at the concentration of 17500mg/kg bw viaoral route. 50 % mortality observed at 17500 mg/kg bw. Therefore, LD50 was considered to be 17500 mg/kg bw, when hooded rats was treated with Terphenyl, hydrogenated via oral route.
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