Registration Dossier
Registration Dossier
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EC number: 230-819-0 | CAS number: 7328-91-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dimethylpropane-1,3-diamine
- EC Number:
- 230-819-0
- EC Name:
- 2,2-dimethylpropane-1,3-diamine
- Cas Number:
- 7328-91-8
- Molecular formula:
- C5H14N2
- IUPAC Name:
- 2,2-dimethylpropane-1,3-diamine
- Details on test material:
- Name of the test substance used in the study report: Neopentandiamin (= 1,3-Diamino-2,2-dimethylpropan)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weights: males 191 g, females 164 g
A standardized animal laboratory diet was offered.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Application area: 25 cm2
Application site: back - Duration of exposure:
- 24 h
- Doses:
- 1000 and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Mortality:
- 1000 mg/kg: no deaths after 14 days; 2000 mgkg: all animals died within 48 hours
- Clinical signs:
- Toxic symptoms: intermittently breathing, apathy, staggering, spastic gait, tonic convulsions, trembling
Local skin findings: after 24 hours necrosis was observed, which was not reversible within 14 days - Gross pathology:
- Animals that died: heart: acute dilatation (right), acute congestive hyperemia; kidneys: remarkable pale
Sacrificed animals: nothing abnormal detected
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 dermal for rats was >1000 < 2000 mg/kg bw.
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