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EC number: 242-745-6
CAS number: 19009-56-4
Table 1 presents the clinical observations of the treated animals. In
the initial sighting study (dose of 300mg/kg bw), hunched posture
was noted 1, 2 and 4 hours after dosing. No other signs of systemic
toxicity were noted. For the initial singular animal treated with a dose
level of 2000 mg/kg bw, hunched posture was noted 1, 2 and 4 hours after
dosing in the initial treated animal. No other signs of systemic
toxicity were noted in this animal. No signs of systemic toxicity were
noted in the additional four treated animals during the observation
period. No abnormalities were noted in necropsies of all animals. Table
2 demonstrates the weight changes throughout the study in the individual
test animals. Table 3 demonstrates the necropsy findings of
individual test animals.
Table 1. Individual Clinical Observations and Mortality Data
DOSE LEVEL mg/kg
ANIMAL NUMBER AND SEX
EFFECTS NOTED AFTER DOSING(Hours)
EFFECTS NOTED DURING PERIOD AFTER DOSING(Days)
0 = no signs of systemic toxicity
H = hunched posture
Table 2. Individual body weights and body weight changes
ANIMAL NUMBER & SEX
BODY WEIGHT (g) AT DAY
BODY WEIGHT GAIN (g) DURING WEEK
Table 3. Individual necropsy findings
TIME OF DEATH
Killed day 14
No abnormalities detected
The acute oral toxicity of the test substance was measured using the
fixed dose method (OECD 420 and EU Method B. 1) on the Wistar rat
strain. One rat was given a dose of 300mg/kg bw (sighting test),
followed by one rat given a dose of 2000mg/kg bw, followed by four
further rats given a dose of 2000mg/kg bw. Clinical signs and body
weight development were monitored during the study. All animals were
subjected to gross necropsy.
Under the condition of this study, the acute oral median lethal dose
(LD50) of the test item in the female Wistar strain rat was estimated to
be greater than 2000 mg/kg body weight.
Based on these results, the test item does not have to be classified and
has no obligatory labelling requirement for acute oral toxicity
according to the Globally Harmonized System of Classification and
Labelling of Chemicals (GHS) of the United Nations (2015) (including all
amendments) and Regulation (EC) No 1272/2008 on classification,
labelling and packaging of items and mixtures (including all amendments).
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