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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 Sep - 14 Nov 2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
This study was not conducted in a GLP facility, but was conducted according to international guidelines.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
dynamic method
Key result
Temp.:
20 °C
Vapour pressure:
5.39 Pa
Key result
Temp.:
25 °C
Vapour pressure:
8.24 Pa
Vapour pressure:
56.36 Pa

The measured values together with the measured temperatures are listed in Table 1.

The vapour pressure of the substance was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20°C, 25°Cand 50°C. This is shown in Table 2. Reaction and/or decomposition was not observed during the test.

Table 1. Measurement results of vapour pressure at various temperatures

SAMPLE NAME

TEMPERATURE

VAPOUR PRESSURE

CONDITION

°C

K

Pa

mmHg

Aldehyde C11 MOA

82

355

400

3

Measured up

91

364

800

6

Measured up

100

373

1333

10

Measured up

110

383

2000

15

Measured up

117

390

2800

21

Measured up

119

392

3000

22.5

Measured up

114

387

2466

18.5

Measured up

104

377

1600

12

Measured up

94

367

933

7

Measured up

86

359

533

4

Measured up

Note) Temperature in Kelvin (K) = Temperature in °C+ 273.15

From the measured data points of the vapour pressure curve (with Log P as a function of 1/T), the constants A and B of the Antoine equation were calculated.

Antoine equation: Log P= A+ B*1/(T) P : Vapour pressure in Pa T : Temperature in K A= 11.707

B= -3215.8

Table 2. Estimated vapour pressure

SAMPLE NAME

TEMPERATURE

VAPOUR PRESSURE

°C

K

Pa

mmHg

Aldehyde C11 MOA

20

293

5.39

4.0 x 10-2

25

298

8.24

6.0 x 10-2

50

323

56.36

4.2 x 10-1

Note) Temperature in Kelvin (K) = Temperature in °C+ 273.15

Conclusions:
The vapour pressure of the substance was 5.39 Pa at 20 °C (293 K), 8.24 Pa at 25 °C (298 K) and 56.36 Pa at 50 °C (323 K) (calculated by extrapolation of the measured vapour pressure curve).
Executive summary:

The vapour pressure of the test substance was determined according to the OECD Guideline 104, 23rd March 2006 and EU Method A.4.

The vapour pressure was measured in the temperature range of 82 °C to 119 °C. When the lowest pressure (400 Pa) was then set and the boiling section was heated by an electrical cartridge. At this time, the boiling temperature of the sample reached at 82 °C. When 3000 Pa was set the boiling section was heated by an electrical cartridge heater set up to 300 °C and equilibrium point of the sample was reached at 119°C.

The vapour pressure of the substance was 5.39 Pa at 20 °C (293 K), 8.24 Pa at 25 °C (298 K) and 56.36 Pa at 50 °C (323 K) (calculated by extrapolation of the measured vapour pressure curve). Reaction and/or decomposition of the test material was not observed during the test.

Description of key information

Vapour Pressure = 8.24 Pa at 25 °C; OECD 104; Anon, 2013

Key value for chemical safety assessment

Vapour pressure:
8.24 Pa
at the temperature of:
25 °C

Additional information

In a single key study, the vapour pressure of the test substance was determined according to the OECD Guideline 104, 23rd March 2006 and EU Method A.4.

The vapour pressure was measured in the temperature range of 82 °C to 119 °C. When the lowest pressure (400 Pa) was then set and the boiling section was heated by an electrical cartridge. At this time, the boiling temperature of the sample reached at 82 °C. When 3000 Pa was set the boiling section was heated by an electrical cartridge heater set up to 300 °C and equilibrium point of the sample was reached at 119°C.

The vapour pressure of the substance was 5.39 Pa at 20 °C (293 K), 8.24 Pa at 25 °C (298 K) and 56.36 Pa at 50 °C (323 K) (calculated by extrapolation of the measured vapour pressure curve). Reaction and/or decomposition of the test material was not observed during the test.

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