Registration Dossier
Registration Dossier
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EC number: 946-615-6 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb. 2018 - Apr. 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- preliminary test only
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.24 (Partition Coefficient - HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Remarks on result:
- not determinable
- Remarks:
- not soluble in organic solvent-water mixes
- Conclusions:
- The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow expected >>4).
- Executive summary:
In a non-GLP pre-test, designed to determine suitable HPLC conditions, the test item could NOT be dissolved in any of the organic solvent (methanol, ethanol, acetonitrile, isopropanol, THF) / water mixtures tested, as recommended by OECD 117/EU A24 guideline.
The determination of partition coefficient of the test substance was therefore not possible.
Due to very low water solubility, a high logPow value is considered, as a worst-case.
Reference
In a preliminary feasibility test, the test item could not be dissolved in any of the organic solvent-water mixes.
The only possibility to solve the test object was the use of pure THF, with the addition of 25 % water the test object precipitated again.
An absorption, higher than the blank, was recorded with UV-detector and without a column, but with a C18 column, or with a RI detector (without and with column), no signal could be assigned to the test item.
Description of key information
Experimental determination not feasible.
High log Kow considered (worst-case for bioaccumulation potential).
Key value for chemical safety assessment
Additional information
A fully reliable preliminary test showed that the determination was not experimentally feasible, as the test item is not soluble in organic solvents/water mixes. It is considered as a key study.
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