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EC number: 241-727-5
CAS number: 17736-08-2
According to Article 13 of Regulation (EC) No 1907/2006 "General
Requirements for Generation of Information on Intrinsic Properties of
substances", information on intrinsic properties of substances may be
generated by means other than tests e.g. from information from
structurally related substances (grouping or read-across), provided that
conditions set out in Annex XI are met. Annex XI, "General rules for
adaptation of this standard testing regime set out in Annexes VII to X”
states that “substances whose physicochemical, toxicological and
ecotoxicological properties are likely to be similar or follow a regular
pattern as a result of structural similarity may be considered as a
group, or ‘category’ of substances. This avoids the need to test every
substance for every endpoint”.
A read-across approach was applied to this substance and data was
compiled from representative source substances to avoid unnecessary
animal testing. The target substance will be classified and labelled on
Environmental fate and pathways
Readily biodegradable (85.2% in 28 d, OECD 301 B); read-across
Log Kow ≥ 2.829 (at 24.8°C, OECD 107)
Aquatic acute toxicity
EC50 (48 h) = 0.588 mg a.i./L (geometric mean measured, OECD 202,
ErC50 (72 h) = 12.9 mg a.i./L (TWA, OECD 201, P. subcapitata)
Aquatic chronic toxicity
NOErC (72 h) = 0.63 mg a.i./L (TWA, OECD 201, P. subcapitata)
Classification according to CLP
Based on the available data listed above, the most sensitive acute
effect concentration was obtained for aquatic invertebrates, with an
EC50 (48 h) of 0.588 mg a.i./L (geometric mean measured). Thus, the
substance needs to be classified as environmental hazard Category Acute
1, according to the consolidated version of Regulation (EC) No 1272/2008
(dated: 01.01.2017) and following amendments (ATPs).
M-factor for acute aquatic toxicity: 1.
The NOErC (72 h) of 0.63 mg a.i./L (TWA) for algae is the only
chronic aquatic effect concentration available. In addition, the
substance is readily biodegradable and has a log Kow of ≥ 2.829.
Therefore, the substance is classified and labelled as long-term aquatic
hazard Category Chronic 1, according to the consolidated version of
Regulation (EC) No. 1272/2008 (dated: 01.01.2017) and following
M-factor for chronic aquatic toxicity: not applicable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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