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EC number: 241-727-5
CAS number: 17736-08-2
Oral (OECD 423/EU Method B.1), rats: LD50 > 2000 mg/kg bw (LD50 cut-off
value = 2500 mg/kg bw)
Acute toxicity: oral
An acute oral toxicity study performed according to OECD TG 423 with
(Z)-N-methyl-N-(1-oxo-9-octadecenyl)glycine, compound with
2,2',2''-nitrilotri(ethanol) (1:1) (CAS 17736-08-2) is available
(Charles River, 2016). In this limit test groups of three female Wistar
Crl:WI (Han) rats were administered a single dose of 2000 mg/kg bw of
the test substance via oral gavage. The animals were observed for 14
days after administration. 1/6 females was found dead on Day 3 of the
study period. Clinical signs such as hunched posture and/or piloerection
were noted for the animals between Days 1 and 3. Additionally, lethargy,
flat posture, slow breathing, shallow respiration and hypothermia were
noted for the animal found dead on Days 1 and/or 2. The mean body weight
gain shown by the surviving animals over the study period was considered
to be similar to that expected for normal untreated animals of the same
age and strain. Gross pathology revealed no toxicologically relevant
abnormalities in all animals. Thus, according to OECD 423 TG, the acute
oral LD50 cut-off value was considered to be 2500 mg/kg bw.
The available data on acute toxicity of (Z)-N-methyl-N-(1-oxo-9
-octadecenyl)glycine, compound with 2,2',2''-nitrilotri(ethanol) (1:1)
(CAS 17736-08-2) do not meet the criteria for classification according
to Regulation (EC) No 1272/2008 (CLP). Data therefore are
conclusive but not sufficient for classification.
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