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EC number: 944-209-3
CAS number: -
Revertant counts higher than 1000 were counted and calculated as 1000.
From the data it can be seen that the control plates without mutagens
(negative control) showed numbers of spontaneous colonies within the
ranges of the historical control data of the Laboratory for Toxicology
and Ecology; the positive control chemicals induced without exceptions
large increases in the revertant numbers in the corresponding strains.
The strain characteristics of the stock cultures (rfa-character,
uvrA/uvrB-deletion and resistance to ampicillin and tetracycline) had
Thus, the present study is valid without restrictions.
Precipitation of the test substance in the top agar mixture was observed
from the concentration 62 μg/plate upwards. Compared to the negative
control values, the test substance does not indicate an elevation of the
revertant colonies neither in the absence nor in the presence of S9-Mix.
In a reverse gene mutation assay in bacteria according to OECD guideline
471, 21 July 1997 and EU Method B.13/14, 30 May 2008, strains TA 1535,
TA 1537, TA 98 and TA 100 of S.typhimurium and strain WP2 uvrA of E.coli
were exposed to Amides, C6 -C18, N-[3 -(dimethylamino)propyl] (a.i. 98.4
%). Three independent experiments were performed at concentrations of 0
(control), 62, 185, 556, 1667 and 5000 µg/plate in the first experiment;
0 (control), 1, 4, 11, 33 and 100 µg/plate in the second experiment; 0
(control), 1, 2, 6, 17 and 30 µg/plate in the third experiment all in
the presence and in the absence of mammalian activation.
No evidence of biologically significant mutagenic activity of the test
item was found in the presence and in the absence of metabolic
activation, up to and including the limit concentration of 5000
µg/plate. Biologically significant bacteriotoxic effects were observed
at concentrations >33 µg/plate. Precipitation of the test substance in
the top agar mixture was observed from the concentration 62 µg/plate
upwards. The positive controls induced the appropriate responses in the
corresponding strain and activity of metabolizing system was confirmed. There
was no evidence of induced mutant colonies over background.
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