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EC number: 944-209-3
CAS number: -
1: Number of animals dead (total number of animals: 5 males, 5 females
Dose (mg/kg bw)
Mortality after 24 h(# dead/total)
Mortality after 14 d(# dead/total)
Time range of deaths
24 h – 3 d
24 h – 48 h
an acute oral toxicity study in accordance with the Appraisal of the
safety of chemicals in foods, drugs and cosmetics, by FDA (US) 1959,
groups of fasted male and female young adult Wistar rats were given a
single oral dose of Amides, C8-18 even numbered,
N-[3-(dimethylamino)propyl] at doses of 2000, 2520, 3180, 3980 mg/kg bw
and observed for 14 days.
The substance was administered as 50% suspension in arachis oil warmed
at about 37°C.
the dose groups 2000,
2520, 3180, 3980 mg/kg
bw 30, 50, 60, and 90 % of animals died after 24 hours, respectively.
After 14 days 70, 80, and 100 % of animals died, respectively. In the
dose group 2000 and 2520 mg/kg bw animals were found dead between 24 h
and 3 days. In the two highest dose groups animals were found dead on
the first 24 or 48 hours after application.
effects on body weight were observed. Decreased activity, reduced pain
reaction, light tremor and twitches, obvious disturbance in
coordination, abnormal body posture, decreased grip- and limp tone,
diarrhea and piloerection were observed about 20 minutes after
application and held on partly for 24 hours. Afterwards all animals
showed a normal disposition. At doses from 2520 mg/kg bw upwards the
animals showed in addition emaciated flanks and ptosis. Gross
necropsies performed on the animals which died generally exhibited a
redness of the gastrointestinal mucous membrane. Necropsies performed on
the surviving animals at termination exhibited no gross pathological
LD50(14 days) Males/Females: < 2000 mg/kg bw.
information on content of active ingredient of the test substance in the
study report. However, according to producer information the test
substance has 87 % a.i., therefore the LD50 refering to 100
% a.i. is < 1740 mg/kg bw.
In addition to the 14 d LD50, a 24 h LD50
(Males/Females) of 2570
(95 % CL 2350 - 2790) mg/kg bw was calculated for the product with 87 %
a.i. (this value corresponds to a LD50 of approx. 2236 (95 % CL 2045 -
2427) mg/kg bw) for 100% a.i.).
test substance Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl] was
judged to be slightly toxic based on the oral LD50 (14
days) in male and female rats.
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