Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- The excretion in breath of some aliphatic halogenated hydrocarbons following administration by inhalation.
- Author:
- Morgan, A., et al.
- Year:
- 1 970
- Bibliographic source:
- Ann Occup. Hyg. 13:219-233, as cited in: OECD SIDS Chloromethane, 2004
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- After inhalation as a single breath of 38C-chloromethane by volunteers, to assess distribution and excretion.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
- Details on test material:
- - Name of test material (as cited in study report): 38C-chloromethane
- Analytical purity: no data
Constituent 1
Results and discussion
- Results:
- After inhalation as a single breath of 38C-chloromethane by volunteers, 29% of the inhaled radioactivity was excreted in expired air within one hour. The urinary excretion was < 0.01%/min. Chloromethane was shown to be slower in excretion than predicted based on the blood: air partition coefficient, suggesting it reacts with substances in the bloodstream.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
