Registration Dossier
Registration Dossier
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EC number: 205-011-6 | CAS number: 131-11-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract/table available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A Toxicological Investigation of Some Acute, Short-Term, and Chronic Effects of Administering Di-2-Ethylhexyl Phthalate (DEHP) and Other Phthalate Esters'
- Author:
- Lawrence WH et al.
- Year:
- 1 975
- Bibliographic source:
- Environ. Res. 9: 1-11
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- ECB-IUCLID
- Year:
- 2 000
- Bibliographic source:
- European Chemicals Bureau, 11-FEB-2000
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl phthalate
- EC Number:
- 205-011-6
- EC Name:
- Dimethyl phthalate
- Cas Number:
- 131-11-3
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 1,2-dimethyl benzene-1,2-dicarboxylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 18 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
"a series of doses" (no further data)
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- other: chronic LD50
- Effect level:
- ca. 1 400 other: mg/kg (1.18 mL/kg)
Any other information on results incl. tables
The chronic LD50 was ca. 1400 mg/kg (1.18 ml/kg).
A constant value was reached after 18 weeks.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
