Dimethyl phthalate

Epidemiological data

Administrative data

Endpoint:

epidemiological data

Type of information:

other: review

Adequacy of study:

weight of evidence

Study period:

Articles from Jan 2000 to Aug 2020

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

There is no information given on quality criteria of study inclusion, however the review still gives a good overview of epidemiological studies concerning DMP

Data source

Reference

Reference Type:

publication

Title:

The effects of phthalate ester exposure on human health: A review

Author:

Wei-Hsiang Chang, Samuel Herianto, Ching-Chang Lee, Hsin Hung, Hsiu-Ling Chen

Year:

2021

Bibliographic source:

Science of the Total Environment 786 (2021) 147371

Materials and methods

Study type:

other: review

Endpoint addressed:

other: reproductive diseases, cardiovascular diseases, thyroid disorders, repsiratory diseases, diabetes, obesity, kidney diseases, neurological disorders

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

The study authors attempt to review eight main health effects of phthalate exposure according to the most up-to-date studies.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dimethyl phthalate

EC Number:

205-011-6

EC Name:

Dimethyl phthalate

Cas Number:

131-11-3

Molecular formula:

C10H10O4

IUPAC Name:

1,2-dimethyl benzene-1,2-dicarboxylate

Test material form:

liquid

Method

Type of population:

general

Results and discussion

Any other information on results incl. tables

MMP (the main metabolite of DMP) was not associated with:

-anogenital distance in Japanese newborn (Suzuki, 2012) and in Taiwanese neweborn (Huang, 2009);

-coronary heart disease (Song, 2015);

-thicker carotid-artery intima and media thickness (which itself is associated with the prevalence of cardiovascular disease) in young adults and adolescents in Taiwan (Su, 2019).

A sum parameter of low molecular weight phthalate esters (including MMP) was associated with a lower nonverbal IQ score in children (van den Dries, 2020). However it is unclear if this is of direct relevance.

Higher MMP levels were associated with premature thelarche (Chou, 2009 and Zhang 2015), however the study population was very small with only 89 participants and the relevance is therefore unclear.

MMP was not associated with obesity in children (Xia, 2018). However in another study (Amin, 2018) MMP was associated with obesity in Iranian children. Further there was an association with obesity in Chinese males and females (Li, 2020) and DMP was associated with total cholesterol levels in Chinese serum (Zhang, 2018). The results are somehow inconsistent. However, since DMP is used in food packaging, a correlation (without causality) seems plausible.