Registration Dossier
Registration Dossier
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EC number: 200-842-0 | CAS number: 75-12-7
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Summary report: no detailed information, secondary literature; route of application not relevant for humans.
Data source
Reference
- Reference Type:
- publication
- Title:
- Etude toxicologique de la formamide et de ses dérivés N-Méthylés et N-Ethylés.
- Author:
- Chanh PH, Xuong ND, Azum-Gelade M-C
- Year:
- 1 971
- Bibliographic source:
- Thérapie 26, 409-424.
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to Caujolle, F. et al.: Arzneimittelforschung 20: 1242-1246
- GLP compliance:
- no
Test material
- Reference substance name:
- Formamide
- EC Number:
- 200-842-0
- EC Name:
- Formamide
- Cas Number:
- 75-12-7
- Molecular formula:
- CH3NO
- IUPAC Name:
- formamide
- Details on test material:
- TS-Freetext:
formamide; no data on purity of the compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 7 weeks
- Frequency of treatment:
- once daily, 5 d/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150 mg/kg
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: 24 h
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Depression of body weight gain, leukocytosis, elevated SGOT
and SGPT in blood. No microscopic histological changes in
various tissues.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
