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EC number: 222-048-3
CAS number: 3327-22-8
The key oral study, conducted in a manner similar to (the now deleted) OECD 401 involved gavage administration of one of five doses of a 60% solution of CHPTAC to male and female rats. An LD50 value of 3.2 ml/kg bw was reported (equivalent to 3688 mg/kg bw, or 2213 mg/kg bw for pure CHPTAC). The key dermal study, conducted according to OECD 402, involved 24-h occluded contact with the test material (65% aqeous CHPTAC). An LD50 value in rats in excess of 2348 mg/kg bw was derived for the test material, that has been said to equate to 1526 mg/kg bw for 100% CHPTAC.No suitable data are available for the inhalation route.
The key oral study was
chosen from 4 studies of reliability 2 (reliable with restrictions) as
the most recent of those for which sufficient data were available for
review during entry to IUCLID5. Findings from the remaining three
studies supported those of the key study. Where adequate data were
available the LD50 values for pure CHPTAC were in every case greater
than 2000 mg/kg bw/day. For a further two studies (reliability 4) an
LD50 of >2000 mg/kg bw/day was also given, apparently in relation to an
aqueous solution of CHPTAC, giving a conversion to an LD50 lower than
2000 mg/kg bw/day for the pure substance. However, sufficient details
were not available during entry to IUCLID5 for this to be reliably
The study selected by
FIN to provide the LD50 used in risk characterization (Kynoch
et al., 1982/Dynamit Nobel, 1982) was not available during entry to
IUCLID5. The LD50 value identified in this study is very similar to that
of the key study.
The key dermal study
was chosen from two very similar studies in the rat. The findings of the
supporting study confirm those of the key study
The available data do
not support classification via the oral route (Regulation
(EC) No 1272/2008; Directive
The studies identified
do not indicate classification via the dermal route for the test
(EC) No. 1272/2008; Directive
67/548/EEC). However, conversion to account for the concentration of
CHPTAC in the test material means that the tested dose of pure CHPTAC
was slightly lower than the upper value (2000 mg/kg bw) above which
classification would not be required.
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