Registration Dossier
Registration Dossier
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EC number: 241-774-1 | CAS number: 17796-82-6
Endpoint summary
Administrative data
Description of key information
Additional information
According to peer reviewed data from Hazardous Substances Databank (number7259) an estimated BCF of 130 was calculated for N-(cyclohexylthio)phthalimide (SRC), using a log Kowof 3.66 (US EPA, 2004) and a regression-derived equation (Meylan et al, 1999). According to a classification scheme (Franke et al. 1994), this BCF suggests the potential for bioconcentration in aquatic organisms is high (SRC); however, N-(cyclohexylthio)phthalimide is expected to undergo rapid hydrolysis in aquatic environments (US EPA, 2004).
The partition coefficient was determined also experimentally (using test method – HPLC) (Research Institute for Organic Syntheses Inc., 2007a) according to EU method A.8 Partition coefficient, Directive 92/69/EEC. Partition coefficient (log P) of the N-(cyclohexylthio)phthalimide Log P=3.19 ± 0.37 was measured atand pH= 6.9.
Recalculated bioaccumulation using the latest BCFBAF v3.01 is estimated as BCF = 120.7 L/kg wet-wt (Log BCF from regression-based method = 2.082) using LogKow from expert database: 3.66(Ekotoxikologické centrum Bratislava, s.r.o., 2012a). The result is comparable to value reported by US EPA, 2004. Estimated bioconcentration factor using experimental value of LogKow: 3.19 (Research Institute for Organic Syntheses Inc., 2007a)was lower: 59.12 L/kg wet-wt(Log BCF from regression-based method = 1.772) (Ekotoxikologické centrum Bratislava, s.r.o., 2012a).
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