Registration Dossier
Registration Dossier
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EC number: 241-774-1 | CAS number: 17796-82-6
Endpoint summary
Administrative data
Description of key information
Additional information
According to data from biodegradation in water theN-(cyclohexylthio)phthalimide (CTP)is not ready biodegradable.
Additional information from producer - research done with a waste water inoculum after adaptation - shows that CTP is degradable and based on this the biodegradability characteristics in models were defined as “inherently biodegradable”.
The closed bottle test withN-(cyclohexylthio)phthalimide (purity 98.46%)provided after 28 days 34.9 % of biodegradation (Research Institute for Organic Syntheses Inc., 2007b). In the same test method (closed bottle test provided by the same laboratory) withCTP (purity 99.43%)after 10 days 4.2% biodegradation was observed and after 28 days 16 % of the test substance was degraded (Research Institute for Organic Syntheses Inc., 2007c).
If in the toxicity test, containing both the test substance (CTP) and the reference chemicals, less than 25% degradation occurs in 14 days, the test substance could be assumed to be inhibitory. In both closed bottle tests the degradation was more than 25% therefore the CTPis not inhibiting for microorganism in used inoculum.
Ready biodegradability test according to OECD 301 B: Modified Sturm Test was performed with CTP of purity 79.45%.After a period of 28 days a 48 % biodegradation was observed.In the parallel test with CTP and without inoculum the 44% of biodegradation was observed, therefore the main part of observed biodegradation was due to rapid abiotic degradation in water environment (Slovak environmental Agency – COH, 2007).
Contrary result was observed in peer reviewed data from Hazardous Substances Databank (number7259), whereN-(cyclohexylthio)phthalimidewas found to degrade more than 99% after 160 hours in a semi-continuous activated sludge test (primary biodegradation) using adapted sewage (US EPA, 2004), but we have no full data to assess the report.
Chudoba J, et al. (1986)found, thatN-(cyclohexylthio)phthalimideis inhibiting nitrification in wastewater.
According to peer reviewed data from Hazardous Substances Databank (number7259) soil microorganisms were found to not colonize onN-(cyclohexylthio)phthalimidein experiments using soil burial techniques (Williams, 1984).
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