Registration Dossier
Registration Dossier
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EC number: 205-743-6 | CAS number: 149-57-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
2-EHA was negative in the bacterial Ames test with S. typhimurium strains TA 98, TA 100, TA 1535 and TA 1537 and E. coli WP2 uvr A (Jung et al., 1982; Zeiger et al., 1988; Warren et al., 1982), as well as in a HPRT locus assay with mammalian CHO cells (Schulz et al., 2007). In cultured human lymphocytes, 2-EHA induced a minimal increase in frequency of sister-chromatid exchanges (below 1.5 fold increase at concentrations of the test substance of 0.63 to 2.5 mM; Sipi et al., 1992), which is not considered significant.
In an in vivo micronucleus assay with mice, 2-EHA was administered by gavage up to the maximum tolerated oral dose of 1600 mg/kg/day. No bone marrow toxicity was observed, nor did the test substance induced any bone marrow micronuclei (Holstrom et al., 1994).
Short description of key information:
Overall, 2-EHA is considered not to be genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available data, there is no concern for genotoxicity. Classification according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 is therefore not warranted.
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