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EC number: 205-743-6 | CAS number: 149-57-5
Endpoint summary
Administrative data
Description of key information
2-EHA is practically non-toxic via the oral, dermal and inhalative route. The following values are taken into account for the risk assessment: LD50 (oral;rat): 3640 mg/kg bw; LD50 (dermal,rat) >2000 mg/kg bw; no acute toxicity from inhalative exposure to saturated vapor
Key value for chemical safety assessment
Additional information
Valid acute toxicity studies after oral, dermal and inhalative exposure are available for 2-EHA.
In an acute oral toxicity study 4 rats/sex/dose were dosed with 90, 722, 1445 or 2890 mg/kg bw. No mortality was observed in the 90, 722 and 1445 mg/kg bw dose groups. The test material caused mortality in rats administered a dose of 2890 mg/kg bw (4/4), and transitory weakness at lower doses in a dose-dependent manner. The LD50 was calculated to 2043 mg/kg bw.
In another acute oral toxicity study 5 rats/sex/dose have been administered 0.2, 1.6, 3.2 and 4.0 ml 2 -EHA/ kg bw. No substance related clinical signs nor mortality was observed at 0.2 and 1.6 ml/kg. However, 1/10 animals died. After administration of 3.2 ml/kg and 4 ml/kg apathy, dyspnea, abdominal position and recrusted eyes and snouts were observed. Mortality in these dose groups was 3/10 and 5/10, respectively. The LD 50 was estimated to be 4 mL/kg bw, being equivalent to 3640 mg/kg bw (density 0.91 g/ml). This result is supported by another study which however was poorly documented.
No mortality was observed in 12 rats (6 m; 6f) after 8 h exposure to saturated 2-EHA vapor in an inhalation hazard test comparable to OECD 403 Annex 1. Maximal achievable concentration in this test system was 0.11 mg/L (nominal concentration).
Dermal toxicity of 2 -EHA was tested in an OECD 402 guideline study. Five Wistar rats/sex/dose have been exposed dermally (semi-occlusive) to a limit dose of 2000 mg/kg bw 2-EHA. No mortality and no clinical symptoms beside eshar formation have been observed. Therefore, the dermal LD50 is > 2000 mg/kg bw.
Justification for classification or non-classification
Classification for acute toxicity is not warranted according to the criteria of EU Directive 67/548/EEC and according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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