Registration Dossier
Registration Dossier
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EC number: 233-141-3 | CAS number: 10043-67-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no OECD guideline, but well documented
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Production of epidermal damage in mammalian skins by some simple aluminum compounds
- Author:
- Lansdown, AB
- Year:
- 1 973
- Bibliographic source:
- Br. J. Dermatol. 89, 67-76
- Reference Type:
- secondary source
- Title:
- Toxicological Profile for Aluminum
- Author:
- ATSDR
- Year:
- 2 008
- Bibliographic source:
- ATSDR (2008) Toxicological Profile for Aluminium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, p. 91/92
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium sulfate
- IUPAC Name:
- Aluminium sulfate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Carworth TF1
- Details on test animals or test system and environmental conditions:
- female TF1 Carworth mice
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Duration of treatment / exposure:
- 5d/1x/d
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: hyperplasia, micro abscess formation, dermal inflammatory cell infiltration, and occasional ulceration
- Remarks on result:
- other: no skin damage effects
Any other information on results incl. tables
NOAEL-5d/1x/d: 10%, no skin damage effects
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- NOAEL-5d/1x/d: 10 % (w/v), not irritating, no skin damage.Calculated for AlK(SO4)2: 13.25 % (w/v)Therefore the substance is not classified as skin irritating according EU-Regulation No. 1272/2008 (CLP)and EU regulation 286/2011 (2. ATP).
- Executive summary:
NOAEL-5d/1x/d: 10%, not irritating, no skin damage.
Calculated for AlK(SO4)2: 13.25 % (w/v)
Therefore the substance is not classified as skin irritating according EU-Regulation 1272/2008 (CLP)
and EU regulation 286/2011 (2. ATP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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