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EC number: 200-913-6 | CAS number: 75-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: sister chromatid exchange
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only few information on the test conditions. Results are not detailed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of 2,2,2-trifluoroethanol in chinese hamsters and beagle dogs
- Author:
- Marshall TC, Hahn FF, Brooks AL and Hobbs CH
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Chinese hamsters were treated by intraperitoneal route with the test item. Bone marrow cells were then prepared for differential staining of sister chromatids and evaluated for the frequency of sister chromatid exchange as decribed by Stedka and Wolff (Mutation research, 1976, 41:333-342).
- GLP compliance:
- no
- Remarks:
- study performed before GLP compliance
- Type of assay:
- sister chromatid exchange assay
Test material
- Reference substance name:
- 2,2,2-trifluoroethanol
- EC Number:
- 200-913-6
- EC Name:
- 2,2,2-trifluoroethanol
- Cas Number:
- 75-89-8
- Molecular formula:
- C2H3F3O
- IUPAC Name:
- 2,2,2-trifluoroethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2,2,2-trifluoroethanol
- Physical state: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: assumed to be stable during the test (sponsor responsibility)
- Storage condition of test material: no data
- Other: no data
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Strain:
- other: Laboratory-reared (LOV:(CHN))
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: water
- Justification for choice of solvent/vehicle: no data
- Concentration of test material in vehicle: 5,20 or 30 mg/mL dilutions of the substance in water were prepared
- Amount of vehicle (if gavage or dermal): not applicable
- Type and concentration of dispersant aid (if powder): not applicable
- Lot/batch no. (if required): no data
- Purity:no data - Details on exposure:
- no data
- Duration of treatment / exposure:
- the animals were treated for 4 consecutive days
- Frequency of treatment:
- each day for 4 days
- Post exposure period:
- Five hamsters from each dose group were sacrified 1 day after completion of the exposure regimen.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Remarks:
- for 4 consecutive days
- Dose / conc.:
- 5 mg/kg bw/day (nominal)
- Remarks:
- for 4 consecutive days
- Dose / conc.:
- 25 mg/kg bw/day (nominal)
- Remarks:
- for 4 consecutive days
- Dose / conc.:
- 100 mg/kg bw/day (nominal)
- Remarks:
- for 4 consecutive days
- No. of animals per sex per dose:
- the doses were administered to 9 animals per dose level. 5 hamsters from each group were sacrified and bone marrow of 3 animals at each dose were prepared for the SCE assay.
- Control animals:
- yes, concurrent no treatment
- Positive control(s):
- cyclophosphamide
- Justification for choice of positive control(s): no data
- Route of administration: intraperitoneal injection
- Doses / concentrations: 30 mg/kg bw/day for 4 days
Examinations
- Tissues and cell types examined:
- Bone marrow cells from 3 animals at each dose were prepared. 50 cells per animal were counted for SCE.
- Details of tissue and slide preparation:
- No data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- No additional information
Any other information on results incl. tables
No remark
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, 2,2,2-trifluoroethanol is not an in vivo mutagen or may have no direct affect on replicating chromosomes.
- Executive summary:
In a mammalian cell cytogenetics assay (Sister Chromatid exchange assay), 9 male Chinese hamsters (LOV: (CHN)) were exposed to 2,2,2-trifluoroethanol (>99°%) diluted in water at concentrations of 0, 5, 25 and 100 mg/kg bw/day for 4 consecutive days by intraperitoneal injection.
One day after completion of the exposure regimen, bone marrow cells of 3 animals per dose were then prepared for differential staining of sister chromatids and evaluated for the frequency of sister chromatid exchange as decribed by Stedka and Wolff (1976).
Cyclophosphamide was used as positive control and induced the appropriate response.
There was no evidence of sister chromatid exchange induced over background with the test item.
Under the test conditions, 2,2,2-trifluoroethanol is not an in vivo mutagen or may have no direct effect on replicating chromosomes.
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