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EC number: 278-780-9
CAS number: 77881-13-1
A slight but statistically significant increases of micronucleated
polychromatic erythrocyte counts were seen at the low and high dose
groups versus the concurrent negative control at the last sample time
(72 h). However, this increase is biologically not relevant because the
control values in males are unusually low (0.6 ± 0.6) compared to those
of the first and second sample times (1.4± 1.1 and 1.4± 0.6) and
moreover, there was no dose response relationship at all. Additionally,
the biological fluctuation is also weIl characterized by the fact that
the micronucleated normochromatic erythrocyte count in the high dose
group at the last sample time was lower than in all vehicle controls and
ZK 74.804 groups.
The positive control compound triaziquone proved to be toxic and gave
the expected increase in the micronucleated polychromatic cell counts.
To investigate the potential of
AD-Cyanhydrin (= ZK 74.804) to induce chromosome breakage or malfunction
of the spindle apparatus an mouse micronucleus test was conducted. Male
and female NMRI mice were treated once by gavage with 1.0, 2.5 or 5.0
g/kg body weight. Control animals were given the vehicle at 40 ml/kg in
the same manner. Triaziquone (0.15 mg/kg; single i.p. treatment) served
as positive control. Animals of the control and treatment groups were
killed at intervals of 24, 48 and 72 hours after treatment. The positive
control animals were killed 24 hours after treatment. Femur bone marrow
smears were prepared and stained using May-Gruenwald and Giemsa
solutions. The coded slides were examined for the presence of
micronuclei in 1000 polychromatic and 1000 normochromatic erythrocytes
and for the ratio of polychromatic to normochromatic erythrocytes. The
micronucleated cell counts obtained with ZK 74.804 were comparable with
the concurrent control values. No bone marrow depression was observed.
Therefore, AD-Cyanhydrin showed no mutagenic
potential when administered by gavage up to 5 g/kg in the mouse
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