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EC number: 278-780-9
CAS number: 77881-13-1
Table 1: Biological degradation (cumulative) in percent (corrected for
blank CO2-production) of AD-Cyanhydrin
The purpose of this study was to determine the ready biodegradability of
AD-Cyanhydrin, an intermediate of the synthesis of hydroxyprogesterone
(ZK 5149). The study was conducted in agreement with the following test
OECD guideline for testing of chemieals, Ready biodegradability:
C02-evolution test, no. 301 B, adopted Jul. 92, OECD Paris, 93.
The test substance was incubated in an aqueous solution including
nutrients with microorganisms from a municipal sewage treatment plant
for 28 days (start of treatment = day 1). The nutrient solutions were
made up of phosphates, magnesium sulphate,
iron chloride, ammonium chloride and calcium chloride.
The test substance was incubated in a concentration of 10 mg carbon/I in
triplicate. Additionally, a reference substance (sodium acetate) was
tested in a single set according to the same procedure, in order to
verify the viability and activity of the degrading microorganisms. One
further set was incubated with sodium acetate at 10 mg carbon/L
plus test substance at 10 mg carbon/L representing a toxicity control.
Furthermore, a blank control
was tested in triplicate without any test or reference substance.
The biological degradation of the test and reference substances was
evaluated by measurement of the carbon dioxide (C02) produced during the
The test compound AD-Cyanhydrin was degraded to 38% on day 11 (10 days
of incubation) and up to 77% on day 30 (28 days of incubation). The
degradation started after a short lag-phase. The reference compound
sodium acetate was degraded to more than 60% on day 11 and up to 86% on
In the toxicity control, the reference compound (sodium acetate) plus
the test compound was degraded up to 90% on day 30, which corresponded
to the degree of degradation expected on the basis of the observations
with the individual compounds.
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