Registration Dossier
Registration Dossier
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EC number: 234-456-9 | CAS number: 12004-39-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A key study is provided for the assessment of growth inhibition in algae. The study was conducted in accordance with the appropriate OECD test guideline, with analytical confirmation of exposure concentrations, with no deviations and in compliance with GLP. The 72-hour EC50 was found to be >0.210 mg/L and the NOEC was determined to be 0.210 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.21 mg/L
- EC10 or NOEC for freshwater algae:
- 0.021 mg/L
Additional information
Key study
The inhibitory effect of dialuminium titanium pentaoxide on algal growth was determined in a 72 hour growth inhibition test withPseudokirchneriella subcapitata, conducted in accordance with OECD guideline 201. The algae were exposed to the test substance at loading rates of 0 (control), 10, 18, 32, 56 and 100 mg/L. Concentrations of dissolved aluminium and titanium were determined by ICP-MS which were then used to calculate equivalent concentrations of the test substance present in the test solutions. Test media were not renewed during the 72 hours.
The 72hr ErC50 based on aluminium analysis was determined to be >0.388 mg/L. The 72hr ErC50 based on titanium analysis was determined to be >0.274 mg/L in the standard growth medium and >0.210 mg/L in the enhanced growth medium. The 72hr NOECr based on titanium analysis was determined to be 0.210 mg/L in enhanced growth medium.
The NOECr for the standard medium occurred at the 10 mg/L loading rate, while the NOEC for the enhanced medium occurred at 100 mg/L. As concentrations of test substance measured were comparable in the 100 mg/L treatments of both the standard and enhanced media, it was suggested that the effect of the test substance in the standard medium was due to decreased bioavailability of nutrients caused by aluminium and titanium forming complexes with components of the test media. This is not considered to be a toxicological effect and as such is not used for derivation of NOEC of endpoints.
No unusual cell shape or agglutination was observed at any test concentration after 72 hours.
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