Registration Dossier
Registration Dossier
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EC number: 611-631-1 | CAS number: 58190-57-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The analogue substance Wasox-VMAC2, which shares the same functional groups with EAC3, also has comparable values for the relevant molecular properties and are toxicologically equivalent for the skin sensitisation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Read-across
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Principles of method if other than guideline:
- Read-across approach from experimental data (according to OECD Guideline 429 and GLP) on analogue substance Wasox- VMAC2.
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
- IUPAC Name:
- acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
- Reference substance name:
- 797751-44-1
- Cas Number:
- 797751-44-1
- IUPAC Name:
- 797751-44-1
- Reference substance name:
- A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
- EC Number:
- 458-680-3
- EC Name:
- A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
- IUPAC Name:
- 458-680-3
- Details on test material:
- - Name of test material (as cited in study report): Wasox-VMAC2
- Molecular formula (if other than submission substance): Not applicable, multiconstituent substance
- Molecular weight (if other than submission substance): 231.627
- Smiles notation (if other than submission substance): Not applicable, multiconstituent substance
- InChl (if other than submission substance): Not applicable, multiconstituent substance
- Structural formula attached as image file (if other than submission substance): see Fig.
Constituent 1
Constituent 2
Constituent 3
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Results based on analogue substance Wasox-VMAC2: Negative Control: 1 Low Dose: 1.2 Mid Dose: 1.0 High Dose: 0.7 Positive Control: 10.2
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Results based on analogue substance Wasox-VMAC2: Negative Control: 4197dpm Low Dose: 4964 dpm Mid Dose: 4383 dpm High Dose: 2736 dpm Positive Control: 42767 dpm
Any other information on results incl. tables
See "Data Matrix" and "Reporting Format" attached.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on read-across approach from analogue substance Wasox-VMAC2 (OECD Guideline 429, GLP study), the test item EAC3 was determined to be not sensitising.
- Executive summary:
Based on the experimental results with analogue substance Wasox-VMAC2 which was considered to be not sensitising according to OECD Guideline 429 and GLP, the read-across approach was applied and the test item EAC3 was also considered to be not sensitising under test conditions.
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