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EC number: 903-945-5 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No data on long-term toxicity to fish is available on the reaction mass of chlorodifluoroacetic acid (CDFA) and trifluoroacetic acid (TFA).
One reliable data is available on the main constituent of the reaction mass, i.e. CDFA. This study was performed according to the OECD testing guideline 204 “Fish, Prolonged Toxicity Test: 14-day Study” (1984) under semi-static conditions of 72 h-renewal. The threshold levels of lethal and other observed effects in fish (Brachydanio rerio) exposed to Chlorodifluoroacetic acid for 14 days were determined.
During the whole test period, the pH values of the control and Test Media were between 7.2 and 7.3, and the Dissolved Oxygen (DO) values varied from 88% to 99% of the air saturation at the test temperature, and the temperature of the Test Media was maintained in the range of 22°C to 23°C. All fishes in the control group were normal. So the study met the acceptability criteria.
For mortality, the NOEC was 40 mg/L (measured concentration 41.8 mg/L). No effect on behaviour, length and weight of organisms were observed during the study, therefore the NOEC is >= of the highest tested concentration of 60 mg/L (measured concentration 57.9 mg/L).
The 14d fish test is not considered as a chronic test because the sensitive life-stages (juveniles, eggs, larvae) are not exposed. It is, in effect, prolonged acute studies with fish mortality as the major endpoint examined. However, the results from this reliable study showed no effect to the growth of juvenile fish up to the highest tested concentration of 60 mg/L and an EC50 for the most sensitive species, the algae, was determined at 7.7 mg/L. Therefore, a chronic test with fish is not considered necessary to improve the PNECs neither for the classification process.
No data is available on TFA. The results from a valid acute test on fish showed no toxicity of TFANa up to the highest concentration tested (1200 mg/L) and an EC50 for the most sensitive species, the algae, was determined at 10.2 mg/L. Therefore, a chronic test with fish is not necessary to improve the PNECs neither for the classification process.
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