Registration Dossier
Registration Dossier
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EC number: 903-945-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Only one reliable aquatic toxicity data is available on the reaction mass of chlorodifluoroacetic acid and trifluoroacetic acid. It is an acute toxicity study with Daphnia magna.
For the other aquatic toxicity endpoints, no data is available on the reaction mass of chlorodifluoroacetic acid (CDFA) and trifluoroacetic acid (TFA). But, in the aquatic environment, both constituents (i.e. CDFA and TFA) will be present and will define the ecotoxicity profile of the reaction mass. Therefore, in the present dossier the key studies available on both constituents are reported in the Endpoint Study Records, and a conclusion on the reaction mass is performed in the Endpoint Study Summaries.
This strategy is possible due to similar physico-chemical properties and ecotoxicity profile of both constituents. Indeed, both substances are liquids highly soluble in water with a moderate vapour pressure and a low logKow. Both substances are acids with low pKa and will therefore be dissociated into the environmental compartments. CDFA is slightly more toxic than TFA, and it is the main constituent of the reaction mass, therefore its toxicity will be considered to conclude on the reaction mass.
It should be noted that for TFA, the substance tested in ecotoxicity studies is the sodium salt of trifluoroacetic acid. The read-across approach is relevant for the assessment of the ecotoxicity profile as in the environment this acid is neutralised by cations in presence, including Na+. Moreover, the acidic effect on aquatic organisms is not taken into account for the derivation of PNEC and the environmental classification. Trifluoroacetic acid and sodium trifluoroacetate are both very soluble in water and have a low logKow, therefore their availability to the aquatic organisms is considered as similar.
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