Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary quotation, acceptable review. Data is suitable for read-across.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1980
Reference Type:
secondary source
Title:
Toxicological profile for titanium tetrachloride.
Author:
ATSDR
Year:
1997
Bibliographic source:
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Materials and methods

Principles of method if other than guideline:
Rats were exposed to the test substance via inhalation (head only). The LC50 (4h) was determined.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
IUPAC Name:
titanium tetrachloride
Details on test material:
- Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data
No further data available

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
head only
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
0.46 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Death was attributed to pulmonary edema.
Mortality:
Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.

Applicant's summary and conclusion

Categories Display