Registration Dossier
Registration Dossier
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EC number: 231-728-9 | CAS number: 7705-07-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary quotation, acceptable review. Data is suitable for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Reference Type:
- secondary source
- Title:
- Toxicological profile for titanium tetrachloride.
- Author:
- ATSDR
- Year:
- 1 997
- Bibliographic source:
- Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Materials and methods
- Principles of method if other than guideline:
- Rats were exposed to the test substance via inhalation (head only). The LC50 (4h) was determined.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- IUPAC Name:
- titanium tetrachloride
- Details on test material:
- - Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data
No further data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- head only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.46 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Death was attributed to pulmonary edema.
- Mortality:
- Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.
Applicant's summary and conclusion
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