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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary quotation, acceptable review. Data is suitable for read-across.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1980
Reference Type:
secondary source
Title:
Toxicological profile for titanium tetrachloride.
Author:
ATSDR
Year:
1997
Bibliographic source:
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Materials and methods

Principles of method if other than guideline:
Rats were exposed to the test substance via inhalation (head only). The LC50 (4h) was determined.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
IUPAC Name:
titanium tetrachloride
Details on test material:
- Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data
No further data available

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
head only
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
0.46 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Death was attributed to pulmonary edema.
Mortality:
Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.

Applicant's summary and conclusion