Registration Dossier
Registration Dossier
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EC number: 231-728-9 | CAS number: 7705-07-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary quotation, acceptable review. Data is suitable for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Reference Type:
- secondary source
- Title:
- Toxicological profile for titanium tetrachloride.
- Author:
- ATSDR
- Year:
- 1 997
- Bibliographic source:
- Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Materials and methods
- Principles of method if other than guideline:
- Rats were exposed to the test substance via inhalation (head only). The LC50 (4h) was determined.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- IUPAC Name:
- titanium tetrachloride
- Details on test material:
- - Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data
No further data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- head only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 0.46 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Death was attributed to pulmonary edema.
- Mortality:
- Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
