Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and suitable for read-across.

Data source

Reference
Reference Type:
publication
Title:
Titanium tetrachloride burns to the eye
Author:
Chitkara DK, McNeela BJ
Year:
1992
Bibliographic source:
British Journal of Ophthalmology 76: 380-382

Materials and methods

Study type:
clinical case study
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
Eight cases of chemical burns of the eyes from titanium tetrachloride are presented.
GLP compliance:
no
Remarks:
not applicable

Test material

Constituent 1
Reference substance name:
7750-45-0
Cas Number:
7750-45-0
IUPAC Name:
7750-45-0
Details on test material:
- Name of test material (as cited in study report): Titanium tetrachloride

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 8
- Sex: All male
- Age: 19 - 46 years old
- Race: unknown
Ethical approval:
not applicable
Route of exposure:
ocular
Reason of exposure:
accidental
Details on exposure:
All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body, mainly face, eyes, and skin.

Results and discussion

Clinical signs:
The severity of the clinical signs was dependent on the exposure. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, and pulmonary oedema.

Applicant's summary and conclusion