Registration Dossier
Registration Dossier
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EC number: 231-728-9 | CAS number: 7705-07-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and suitable for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- Titanium tetrachloride burns to the eye
- Author:
- Chitkara DK, McNeela BJ
- Year:
- 1 992
- Bibliographic source:
- British Journal of Ophthalmology 76: 380-382
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- Eight cases of chemical burns of the eyes from titanium tetrachloride are presented.
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- 7750-45-0
- Cas Number:
- 7750-45-0
- IUPAC Name:
- 7750-45-0
- Details on test material:
- - Name of test material (as cited in study report): Titanium tetrachloride
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 8
- Sex: All male
- Age: 19 - 46 years old
- Race: unknown - Ethical approval:
- not applicable
- Route of exposure:
- ocular
- Reason of exposure:
- accidental
- Details on exposure:
- All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body, mainly face, eyes, and skin.
Results and discussion
- Clinical signs:
- The severity of the clinical signs was dependent on the exposure. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, and pulmonary oedema.
Applicant's summary and conclusion
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