(1-methylethyl)-1,1'-biphenyl

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study based on national standard, acceptable for assessment, but with limited documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Code of Federal Regulation - 16 CFR, Part 1500.3

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

25640-78-2 + 69009-90-1

IUPAC Name:

25640-78-2 + 69009-90-1

Constituent 2

Reference substance name:

(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-

IUPAC Name:

(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-

Details on test material:

- Name of test material (as cited in study report): MIPB, isopropyl biphenyl
- Substance type: organic
- Physical state: liquid
- Lot-No. A-36477

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Bunnyville Farms, littletown, Pennsylvania
- Age at study initiation: no data
- Weight at study initiation: 2.3 - 3.1 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: one square inch (6.25 cm²); 2/4 animals per group, abraded or nonabraded skin
- Type of wrap if used: gauze patch wrapped with nonadsorbant binder.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with tap water

Duration of exposure:

24 h

Doses:

4640 and 6000 mg/kg bw

No. of animals per sex per dose:

4 per dose, in total 8 animals

Control animals:

not required

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

not applicable

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality, except
1/4 animals (group 4640 mg/kg) on day 2, but considered unrelated to the treatnment and was replaced.

Clinical signs:

other: Depression in all animals but 1/4 in the 6000-mg/kg group, anorexia in 3/4 and phonation in 1/4 animals in the 4640-mg/kg group.

Gross pathology:

1/4 animals jelly-like material in the intestines,
no other particular findings in any of the other animals.

Other findings:

Signs of dermal irritation observed in all of the rabbits at the 4640 mg/kg level included slight to moderate erythema and slight desquamation.
At the 6000 mg/kg level, slight to moderate erythema and slight desquamation occurred in all of the animals with the findings being of longer duration in the abraded site animals. Edema occurred on Day 1 in one intact site animal.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU