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EC number: 247-156-8
CAS number: 25640-78-2
For assessment of the short-term toxicity to aquatic invertebrates, three studies are available. Two have been performed with (1-methylethyl)-1,1'_biphenyl as test substance. In one study, the supporting substance, 4-ethylbiphenyl, was used. Results of all three studies are close together.
For the substance
monoisopropylbiphenyl (MIPB, (1-methylethyl)-1,1'-biphenyl) two acute
daphnia immobilisation tests were identified. One is a study according
to OECD TG 202 under GLP conditions (Muckle/LAUS, 2012). Test material
was the substance isopropylbiphenyl (mixture of isomers) from RÜTGERS
Novares GmbH which is subject of registration. Test substance
concentrations in test medium were measured. Results are based on
geometric means of measured concentrations. Reliability of this study is
assessed to be 1.
The second study is a pre-guideline
pre-GLP study following the principles of OECD TG 202 (Mendoza/DOW,
1981). Test substance was a mixture of two isomers of
(mono)isopropylbiphenyl from Functional Products & Systems, TS&D,
intended for use as capacitor fluid. Composition is slightly different
from the Applicant´s substance monoisopropylbiphenyl. There is no
information if reported results are derived from measured or nominal
concentrations. Reporting of this study is somewhat limited and
reliability was assessed to be 2. Results of the two studies are quite
Muckle/LAUS 2012: 48 h
EC50 = 0.24 mg/L
Mendoza/DOW 1981: 48 h EC50 = 0.167
For the supporting substance,
4-ethylbiphenyl, data from a short-term daphnia test according to OECD
TG 202 are available (CHRIP/NITE 1999). 48 h EC50 is 0.27 mg/L which is
in good agreement with the result of Muckle/LAUS.
As the study of Muckle/LAUS 2012 was
performed using as test material the substance to be registered and the
reliability is assessed to be high (1), this result is used to
characterise the short-term toxicity of (1-methylethyl)-1,1'-biphenyl to
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