Registration Dossier
Registration Dossier
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EC number: 213-339-6 | CAS number: 938-18-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4,6-trimethylbenzoyl chloride
- EC Number:
- 213-339-6
- EC Name:
- 2,4,6-trimethylbenzoyl chloride
- Cas Number:
- 938-18-1
- Molecular formula:
- C10H11ClO
- IUPAC Name:
- 2,4,6-trimethylbenzoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): 2,4,6-Trimethylbenzoylchlorid
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Herilan, Eggersmann KG
- Age at study initiation:
- Weight at study initiation: males: 180 - 220g, females: 170 - 180g
- Fasting period before study: 15 - 20h
- Acclimation period: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 63.2%; 52.2%; 43%; 35.6%; 29.4%
- Justification for choice of vehicle:
MAXIMUM DOSE VOLUME APPLIED: 5ml/kg - Doses:
- 3160mg/kg
2610mg/kg
2150mg/kg
1780mg/kg
1470mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 15, 30, 60, 120min after application, daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, weighing (days 2-4, 7, 13) - Statistics:
- Finney, D.J., Probit analysis, Cambridge university press, 3red edition, 1971
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 2 055 - < 2 603
- Mortality:
- 3160mg/kg: 4/5 males and 4/5 females died
2610mg/kg: all males and 4/5 females died
2150mg/kg: 3/5 males and no females died
1780mg/kg: 1 male and 1 female died
1470mg/kg: no animals died - Clinical signs:
- other: dyspnoe, apathy, staggering gait, bad general state in all groups piloerection in all but the lowest group spastic gait in the three highest dosages abnormal position in the two highest dosages agitation in the highest dose trembling in the second highest
- Gross pathology:
- dead animals:
acute dilations (heart), congestions, erosive gastritis (large areas affected), severely reddened small intestine, bloody content
animals sacrificed on day 14:
thickened forestomach; button ulcers; liver, spleen, and peritoneum grown together
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Conclusions:
- The acute oral toxicity of the test substance was 2300mg/kg in rats.
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